Recombinant Murine Interleukin-22 (rMuIL-22)

英文全名

Recombinant Murine Interleukin-22 (rMuIL-22)

英文别名

IL-TIF, IL-TIF alpha, IL-22a

蛋白结构

Squence of Recombinant Murine Interleukin-22

氨基酸序列

LPVNTRCKLE VSNFQQPYIV NRTFMLAKEA SLADNNTDVR LIGEKLFRGV SAKDQCYLMK QVLNFTLEDV LLPQSDRFQP YMQEVVPFLT KLSNQLSSCH ISGDDQNIQK NVRRLKETVK KLGESGEIKA IGELDLLFMS LRNACV

Accession

Q9JJY9

Gene ID

50929

产品英文概述

IL-22 is belonging to IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes and dendritic cells, IL-10 contributes to the inflammatory response in vivo. IL-22 signals through CRF2-4 and IL-22. It along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells. IL-22 likely plays a role in the coordinated response of both adaptive and innate immune systems. Recombinant mouse interleukin-22 contains 147 amino acids and it has approximately 81 % and 92 % amino acid sequence identity with human and rat IL-22.

来源

Escherichia coli.

分子量

Approximately 16.6 kDa, a single non-glycosylated polypeptide chain containing 146 amino acids.

生物活性

Fully biologically active when compared to standard. The ED50 as determined by inducing IL-10 secretion of human COLO 205 cells is less than 0.2 ng/ml, corresponding to a specific activity of > 5.0 × 106 IU/mg.

外观

Sterile filtered white lyophilized (freeze-dried) powder.

配方

Lyophilized from a 0.2 um filtered concentrated solution in 1 × PBS, pH 7.4.

内毒素

Less than 1 EU/ug of rMuIL-22 as determined by LAL method.

溶解说明

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.

储存条件

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.

参考资料

纯度

> 96 % by SDS-PAGE and HPLC analyses.
SDS-PAGE of Recombinant Murine Interleukin-22

包装规格

10ug/100ug/500ug

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品牌链接

Recombinant Murine Interleukin-22是ChemWhat品牌授权产品并通过沃尔森销售,下面是ChemWhat上的该产品链接Recombinant Murine Interleukin-22 (rMuIL-22)