Recombinant Human Growth Regulated Protein-gamma/CXCL3 (rHuGRO-gamma/CXCL3)

英文全名

Recombinant Human Growth Regulated Protein-gamma/CXCL3 (rHuGRO-gamma/CXCL3)

英文别名

GRO-gamma, MIP2-beta

蛋白结构

Squence of Recombinant Human Growth Regulated Protein-gamma/CXCL3

氨基酸序列

ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN

Accession

P19876

Gene ID

2921

产品英文概述

CXCL3, also named GRO-gamma, is belonging to the CXC chemokine family and encoded by the gene CXCL3. CXCL3/GRO-gamma shares 86 % amino acid sequence with CXCL1/GRO-alpha. All three human GROs (GRO-alpha, GRO-β, GRO-gamma) are members of the intercrine alpha (chemokine C-X-C) subfamily of chemokines. This chemokine is secreted by monocytes and macrophages. The functional receptor for CXCL3 has been identified as CXCR2. Similar to other GRO proteins, CXCL3 is potent neutrophil attractants and activators. CXCL3 plays a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. All three GROs can bind with high affinity to the IL-8 receptor type B.

来源

Escherichia coli.

分子量

Approximately 7.9 kDa, a single non-glycosylated polypeptide chain containing 73 amino acids.

生物活性

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected human 293 cells is in a concentration range of 10-100 ng/ml.

外观

Sterile filtered white lyophilized (freeze-dried) powder.

配方

Lyophilized from a 0.2 um filtered concentrated solution in 20 mM PB, pH 7.4, 50 mM NaCl.

内毒素

Less than 1 EU/ug of rHuGRO-gamma/CXCL3 as determined by LAL method.

溶解说明

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

储存条件

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.

参考资料

纯度

> 97 % by SDS-PAGE and HPLC analyses.
SDS-PAGE of Recombinant Human Growth Regulated Protein-gamma/CXCL3

包装规格

10ug/100ug/500ug

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品牌链接

Recombinant Human Growth Regulated Protein-gamma/CXCL3是ChemWhat品牌授权产品并通过沃尔森销售,下面是ChemWhat上的该产品链接Recombinant Human Growth Regulated Protein-gamma/CXCL3 (rHuGRO-gamma/CXCL3)