mRNA Cap 2′-O-Methyltransferase, GMP-Grade (GMP-MEH-VE101), DMF #038029, Accession:

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  • 产品概述
  • 产品规格
  • 运输及存储
  • 品牌声明

    • 产品概述

    产品描述

    mRNA Cap 2′-O-Methyltransferase, utilizing S-adenosylmethionine (SAM) as a methyl group donor, adds a methyl group at the 2′-O position of the first nucleotide adjacent to the Cap0 structure at the 5′ end of RNA to obtain m7Gppp5’mN Cap1 structure. Cap1 structure is a signature of self RNA.and has been shown to modulate binding of innate immune sensors. For instance, the binding affinity of IFIT-1 for Cap1 is much weaker than for 5′ triphosphate or Cap0 structure; Cap1 structure abrogates RIG-1 signaling and prevents detection by MDA5. NOTE: Vaccinia Capping Enzyme #GMP-VCS-VE101) is required to generate Cap0 structure. This product has been filed with the FDA Drug Master Files (DMF) and is assigned DMF #038029.

    Biotinylated

    产品规格

    靶点

    分子别名

    Accession

    种属

    蛋白序列

    分子量

    活性

    产品标签

    表达系统

    纯度

    内毒素

    运输及存储

    产品外观

    Liquid

    运输条件

    Shipped with blue ice

    制剂

    复溶

    存储和稳定性

    -20±5°C for 24 months. Avoid repeated freeze-thaw cycles.

    该产品的品牌ChemWhat是Watson的注册商标，由Watson授权江苏沃尔森在中国大陆地区使用，ChemWhat官方网址.